ZINC02092166

Names

[ Name ]:
ZINC02092166

[Synonym ]:
4-Amino-N'-[(9Z)-9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene]-1,2,5-oxadiazole-3-carbohydrazide
1,2,5-Oxadiazole-3-carboxylic acid, 4-amino-, 2-[(9Z)-9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene]hydrazide

Biological Activity

[Description]:

ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs.

[References]

References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₇N₉O₃

[ Molecular Weight ]:
349.264

[ Exact Mass ]:
349.067200

[ LogP ]:
2.05

[ Index of Refraction ]:
2.082