LDN-0088050

Names

[ Name ]:
LDN-0088050

Biological Activity

[Description]:

LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> FABP

[Target]

Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1] Kd: 2.05 μM (FABP4)[1]

[In Vitro]

LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1].

[References]

[1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. Bioorg Med Chem. 2016 Sep 15;24(18):4310-4317.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈BrNO₂

[ Molecular Weight ]:
372.26

Related Compounds

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