TQS

Names

[ Name ]:
TQS

[Synonym ]:
PSB 11 hydrochloride

Biological Activity

[Description]:

TQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

nAChR[1]

[In Vivo]

TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus[1]. Animal Model: Male C57BL/6J mice[1] Dosage: 1 or 4 mg/kg Administration: I.p. Result: Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.

[References]

[1]. Abbas M, et al. The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice. Drug Discov Ther. 2017;11(4):206-211.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀N₂O₂S

[ Molecular Weight ]:
376.47100

[ Exact Mass ]:
376.12500

[ PSA ]:
80.57000

[ LogP ]:
6.23280

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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