Ferric Citrate

Names

[ Name ]:
Ferric Citrate

[Synonym ]:
Citric acid iron
MFCD00013098
Iron citrate
Citric acid, iron salt
Iron(3+) citrate
EINECS 219-045-4
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron (3+) salt (1:1)
Iron(iii) citrate
Citric acid, iron (3+) salt (1:1)
Ferric citrate
EFRRIC CITRATE
Einecs 222-536-6
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
Citric acid iron(III) salt
Iron(III)citrate

Biological Activity

[Description]:

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research.

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death[1]. Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner[1]. Cell Viability Assay[1] Cell Line: Cardiomyocyte (CM) cells Concentration: 1 mM Incubation Time: 24 hours Result: Significantly induced CM cell death.

[In Vivo]

Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival[3]. Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can increase transferrin saturation, serum ferritin, and hemoglobin[2].

[References]

[1]. Yuichi Baba, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H659-H668.

[2]. Julia B Lewis, et al. Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J Am Soc Nephrol. 2015 Feb;26(2):493-503.

[3]. Connor Francis, et al. Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. Kidney Int. 2019 Dec;96(6):1346-1358.

Chemical & Physical Properties

[ Density]:
1.762g/cm3

[ Boiling Point ]:
309.6ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₅FeO₇

[ Molecular Weight ]:
244.945

[ Flash Point ]:
155.2ºC

[ Exact Mass ]:
244.938477

[ PSA ]:
140.62000

[ Vapour Pressure ]:
5.73E-05mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918150000

Customs

[ HS Code ]: 2918150000

[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

Articles

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Ultrastruct. Pathol. 39(1) , 38-48, (2015)

The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic ac...

Evaluation of a modified Cefsulodin-Irgasan-Novobiocin agar for isolation of Yersinia spp.

PLoS ONE 9(8) , e106329, (2014)

Y. enterocolitica and Y. pseudotuberculosis are important food borne pathogens. However, the presence of competitive microbiota makes the isolation of Y. enterocolitica and Y. pseudotuberculosis from ...

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis.

Tuberculosis (Edinb.) 94(6) , 664-71, (2015)

MSMEG_0307 is annotated as a transcriptional regulator belonging to the AraC protein family and is located adjacent to the arylamine N-acetyltransferase (nat) gene in Mycobacterium smegmatis, in a gen...