Vacuolin-1

Names

[ CAS No. ]:
351986-85-1

[ Name ]:
Vacuolin-1

[Synonym ]:
4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(morpholin-4-yl)-N,N-diphenyl-1,3,5-triazin-2-amine
4-[(2E)-2-(3-Iodobenzylidene)hydrazino]-6-(4-morpholinyl)-N,N-diphenyl-1,3,5-triazin-2-amine
Benzaldehyde, 3-iodo-, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone

Biological Activity

[Description]:

A potent PIKfyve inhibitor that inhibits autophagy by impairing lysosomal maturation, potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A; blocks the Ca(2+)-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding, without affecting the process of resealing, induces the formation of giant vacuoles.

[References]

References 1. Cerny J, et al. EMBO Rep. 2004 Sep;5(9):883-8. 2. Shaik GM, et al. Cell Signal. 2009 Aug;21(8):1337-45. 3. Lu Y, et al. Autophagy. 2014;10(11):1895-905. 4. Sano O, et al. FEBS Lett. 2016 Jun;590(11):1576-85. View Related Products by Target Autophagy

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
719.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₄IN₇O

[ Molecular Weight ]:
577.419

[ Flash Point ]:
389.1±35.7 °C

[ Exact Mass ]:
577.108704

[ LogP ]:
4.41

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.706

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.