SB-423557

Names

[ Name ]:
SB-423557

Biological Activity

[Description]:

SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> CaSR

[Target]

IC50: 520 nM (Calcium-sensing receptor)[1]

[In Vivo]

SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls[1].

[References]

[1]. Kumar S, et al. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone. 2010 Feb;46(2):534-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₆N₂O₄

[ Molecular Weight ]:
464.59600

[ Exact Mass ]:
464.26800

[ PSA ]:
91.58000

[ LogP ]:
4.35788

Precursor & DownStream

Precursor

DownStream

Related Compounds

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