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Sulbentine

Names

[ CAS No. ]:
350-12-9

[ Name ]:
Sulbentine

[Synonym ]:
Noticin
Refungine
Fungiplex
Sulbentine
Afungin
3-benzyl-5-phenethyltetrahydro-2H-1,3,5-thiadiazine-2-thione
Dibenzthione
Dibenzthion
3,5-Dibenzyl-tetrahydro-<1,3,5>thiadiazin-2-thion
Carbothialdine
3,5-dibenzyl-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazine-2-thione
Mecal
Dibenzothione

Biological Activity

[Description]:

Sulbentine is an antifungal.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection

[References]

[1]. Thoma K, et al. The photostability of antimycotics. 3. Photostability of locally acting antimycotics. Pharmazie. 1997 May;52(5):362-73.

[2]. Hänel H, et al. Evaluation of fungicidal action in vitro and in a skin model considering the influence of penetration kinetics of various standard antimycotics. Ann N Y Acad Sci. 1988;544:329-37.


[Related Small Molecules]

Cycloheximide | Hygromycin B | Cancidas | 5-Flucytosine | Posaconazole | Terbinafine | Ciclopirox | Isavuconazole | Anidulafungin | Clotrimazole | Clioquinol | Miconazole Nitrate | Pimaricin | Ascomycin | Econazole (nitrate)

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
451.5ºC at 760mmHg

[ Molecular Formula ]:
C17H18N2S2

[ Molecular Weight ]:
314.46800

[ Flash Point ]:
226.9ºC

[ Exact Mass ]:
314.09100

[ PSA ]:
63.87000

[ LogP ]:
3.81330

[ Index of Refraction ]:
1.705

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI2772000
CHEMICAL NAME :
2H-1,3,5-Thiadiazine-2-thione, tetrahydro-3,5-dibenzyl-
CAS REGISTRY NUMBER :
350-12-9
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H18-N2-S2
MOLECULAR WEIGHT :
314.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,558,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 13,574,1964

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%