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SU5205

Names

[ CAS No. ]:
3476-86-6

[ Name ]:
SU5205

[Synonym ]:
3-[(E)-(4-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one
(E)-3-(4-fluorobenzylidene)indolin-2-one
SU 5205

Biological Activity

[Description]:

SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

Flk-1:9.6 μM (IC50)


[In Vitro]

SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC50 of 5.1 μM[1].

[References]

[1]. Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H10FNO

[ Molecular Weight ]:
239.24400

[ Exact Mass ]:
239.07500

[ PSA ]:
29.10000

[ LogP ]:
3.45640

[ Storage condition ]:
-20℃

Related Compounds