Trimethylcolchicinic acid methyl ether
Names
[ CAS No. ]:
3476-50-4
[ Name ]:
Trimethylcolchicinic acid methyl ether
[Synonym ]:
N-deacethylcolchicine
N-deacetylcolchicine
trimethylcolchicinic acid methyl ether
deacetylcolchicine
Desacetylcolchicine
Chemical & Physical Properties
[ Density]:
1.25g/cm3
[ Boiling Point ]:
626.6ºC at 760mmHg
[ Molecular Formula ]:
C20H23NO5
[ Molecular Weight ]:
357.40000
[ Flash Point ]:
287ºC
[ Exact Mass ]:
357.15800
[ PSA ]:
80.01000
[ LogP ]:
3.39450
[ Index of Refraction ]:
1.597
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0785000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-
- CAS REGISTRY NUMBER :
- 3476-50-4
- BEILSTEIN REFERENCE NO. :
- 2822162
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C20-H23-N-O5
- MOLECULAR WEIGHT :
- 357.44
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JZ NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 46 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 49 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 46 mg/kg
- REFERENCE :
- CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950
Safety Information
[ WGK Germany ]:
3
[ HS Code ]:
2922509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%