Incensole acetate

Names

[ Name ]:
Incensole acetate

[Synonym ]:
15-Oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol, 1,5,9-trimethyl-12-(1-methylethyl)-, acetate, (5Z,9Z)-
(5Z,9Z)-12-Isopropyl-1,5,9-trimethyl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl acetate
rel-(1R,2S,5E,9E,12S)-12-isopropyl-1,5,9-trimethyl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl acetate
(1R,2S,5E,9E,12S)-rel-1,5,9-Trimethyl-12-(1-methylethyl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol 2-acetate

Biological Activity

[Description]:

Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole acetate reduces Aβ25–35-triggered apoptosis in hOBNSCs[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

[In Vitro]

Incensole acetate (100 μM; pre-treatment 4 hours) significantly ameliorates Aβ 25–35-induced cell death, a 48–52% decrease in cell viability at Aβ25–35 is restored to 85–89% upon pre-treatment with IA[1]. Incensole acetate (5-100 μM) pretreatment reverses increase in the mRNA and protein level of Bax, caspase 8, cyto c and decrease in the mRNA and protein level of Bcl2 induced by Aβ 25–35 in hOBNSCs[1]. Cell Viability Assay[1] Cell Line: Human olfactory bulb neural stem cells Concentration: 100 μM Incubation Time: Pre-treatment 4 hours Result: Increased hOBNSCs cell viability induced by Aβ 25-35.

[References]

[1]. El-Magd MA, et al. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed Pharmacother. 2018 Sep;105:813-823.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
420.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₆O₃

[ Molecular Weight ]:
348.519

[ Flash Point ]:
178.6±23.3 °C

[ Exact Mass ]:
348.266449

[ PSA ]:
35.53000

[ LogP ]:
6.83

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
-20℃

Related Compounds

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