MIND4-17

Names

[ Name ]:
MIND4-17

[Synonym ]:
MIND4-17
5-Nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}pyridine
5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine
Pyridine, 5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]-
MFCD01899657

Biological Activity

[Description]:

An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.

[References]

References 1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. View Related Products by Target Keap1-Nrf2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
667.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₅N₅O₃S

[ Molecular Weight ]:
405.430

[ Flash Point ]:
357.5±34.3 °C

[ Exact Mass ]:
405.089569

[ LogP ]:
5.49

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.698

Related Compounds

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