(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one
Names
[ CAS No. ]:
34371-14-7
[ Name ]:
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one
[Synonym ]:
2-deoxy-D-erythro-pentono-1,5-lactone
(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-one
2-deoxy-D-ribonolactone
2-Deoxy-ribono-1,4-lactone
Deoxyribonolactone
2-Deoxyribonolactone
2-Deoxy-D-ribono-1,4-lactone
2-Deoxy-D-ribonic-1,4-lactone
Chemical & Physical Properties
[ Density]:
1.438g/cm3
[ Boiling Point ]:
395.3ºC at 760mmHg
[ Molecular Formula ]:
C5H8O4
[ Molecular Weight ]:
132.11500
[ Flash Point ]:
179.1ºC
[ Exact Mass ]:
132.04200
[ PSA ]:
66.76000
[ Index of Refraction ]:
1.521
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2932209090
Synthetic Route
Customs
[ HS Code ]: 2932209090
[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Mutat. Res. Fundam. Mol. Mech. Mutagen. 762 , 32-9, (2014)
A signature of ionizing radiation is the induction of DNA clustered damaged sites. Non-double strand break (DSB) clustered damage has been shown to compromise the base excision repair pathway, extendi...
Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links.Meth. Enzymol. 408 , 48-64, (2006)
DNA base lesions arising from oxidation or alkylation are processed primarily by the base excision repair pathway (BER). The damaged bases are excised by DNA N-glycosylases, which generate apurinic/ap...
Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone.J. Am. Chem. Soc. 134(19) , 8090-3, (2012)
Oxidized abasic sites such as 2-deoxyribonolactone (L) are produced in DNA by a variety of oxidizing agents, including potent cytotoxic antitumor natural products. 2-Deoxyribonolactone is labile under...