TM5007

Names

[ Name ]:
TM5007

[Synonym ]:
5-({6-[(4'-Carboxy-2,3'-bithiophen-5'-yl)amino]-6-oxohexanoyl}amino)-2,3'-bithiophene-4'-carboxylic acid
[2,3'-Bithiophene]-4'-carboxylic acid, 5-[[6-[(4'-carboxy[2,3'-bithiophen]-5'-yl)amino]-1,6-dioxohexyl]amino]-

Biological Activity

[Description]:

TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Izuhara Y, et al. Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):672-7.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
800.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₀N₂O₆S₄

[ Molecular Weight ]:
560.69

[ Flash Point ]:
437.8±34.3 °C

[ Exact Mass ]:
560.020386

[ LogP ]:
4.96

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.730

Related Compounds

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