Glycyrrhetic acid 3-O-mono-beta-D-glucuronide

Names

[ Name ]:
Glycyrrhetic acid 3-O-mono-beta-D-glucuronide

[Synonym ]:
Glycyrrhetyl 3-monoglucuronide
Glycyrrhetic Acid 3-O-Glucuronide
3-monoglucuronylglycyrrhetinic acid
Starrhizin
3-MGA
glycyrrhetic acid mono-glucuronide
Glycyrrhetinic acid 3-O-mono-beta-D-glucuronide

Biological Activity

[Description]:

Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC50 value of 0.28 mM[2]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS‐induced RAW264.7 cells[2].

[References]

[1]. Park HY,et al. Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.Arch Pharm Res. 2004 Jan;27(1):57-60.

[2]. Lichun Guo,et al. Glycyrrhetic Acid 3‐O‐Mono‐β‐d‐glucuronide (GAMG): An Innovative High‐Potency Sweetener with Improved Biological Activities. Comprehensive Reviews in Food Science and Food Safety

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
785ºC at 760mmHg

[ Molecular Formula ]:
C₃₆H₅₄O₁₀

[ Molecular Weight ]:
646.80800

[ Flash Point ]:
240.7ºC

[ Exact Mass ]:
646.37200

[ PSA ]:
170.82000

[ LogP ]:
4.32910

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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