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5-(2,4-Dichlorobenzyl)-2-(2-pyridinyl)-4,6-pyrimidinediamine

Names

[ CAS No. ]:
338965-09-6

[ Name ]:
5-(2,4-Dichlorobenzyl)-2-(2-pyridinyl)-4,6-pyrimidinediamine

[Synonym ]:
5-(2,4-Dichlorobenzyl)-2-(2-pyridinyl)-4,6-pyrimidinediamine
4,6-Pyrimidinediamine, 5-[(2,4-dichlorophenyl)methyl]-2-(2-pyridinyl)-
5-[(2,4-Dichlorophenyl)methyl]-2-(2-pyridinyl)-4,6-pyrimidinediamine
MFCD00231629

Biological Activity

[Description]:

Hepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC50<50 μM. Hepcidin antagonist-1 can be used for researching iron metabolism disorders, such as anemias[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: <50 μM (hepcidin)[1]


[References]

[1]. Franz DÜRRENBERGER, et al. Novel pyrimidine and triazine hepcidine antagonists. WO2011026835

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
476.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H13Cl2N5

[ Molecular Weight ]:
346.214

[ Flash Point ]:
241.8±28.7 °C

[ Exact Mass ]:
345.054810

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.691

Related Compounds

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