Notum-IN-1

Names

[ Name ]:
Notum-IN-1

Biological Activity

[Description]:

Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Notum[1]

[References]

[1]. Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₇Cl₂N₃O

[ Molecular Weight ]:
244.08

Related Compounds

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