Predef

Names

[ CAS No. ]:
338-98-7

[ Name ]:
Predef

[Synonym ]:
(11b)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl Acetate
21-Acetoxy-9-fluoro-11β,17-dihydroxypregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI)
(11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
[2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
9-Fluoroprednisolone 21-acetate
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate
9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
Predef

Biological Activity

[Description]:

Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Isoflupredone acetate (10-4, 10-7, or 10-10 M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7 M and 10-10 M) than the high concentration (10-4 M)[1].

[In Vivo]

Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275)[2]. Animal Model: 96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2] Dosage: 0.05 mg/kg Administration: i.m.; on days 2 and 4 after the challenge Result: Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers.Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
576.5±50.0 °C at 760 mmHg

[ Melting Point ]:
244-246 °C

[ Molecular Formula ]:
C₂₃H₂₉FO₆

[ Molecular Weight ]:
420.471

[ Flash Point ]:
302.5±30.1 °C

[ Exact Mass ]:
420.194824

[ PSA ]:
100.90000

[ LogP ]:
2.46

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3970000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate

CAS REGISTRY NUMBER :: 338-98-7

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H29-F-O6

MOLECULAR WEIGHT :: 420.52

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 120 ug/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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