3-Chloro-4-hydroxyphenylacetic acid
Names
[ CAS No. ]:
33697-81-3
[ Name ]:
3-Chloro-4-hydroxyphenylacetic acid
[Synonym ]:
EINECS 251-643-0
3-chloro-4-hydroxybenzeneacetic acid
3-Chloro-4-hydroxyphenylacetic acid
4-Hydroxy-3-chlorophenylacetic acid
(3-Chloro-4-hydroxyphenyl)acetic acid
MFCD00004349
Benzeneacetic acid, 3-chloro-4-hydroxy-
m-Chloro-p-hydroxyphenylacetic acid
2-(3-Chloro-4-hydroxyphenyl)acetic acid
VUFB9649
4-Hcpa
(3-Chlor-4-hydroxy-phenyl)-essigsaeure
Benzeneacetic acid,3-chloro-4-hydroxy
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
348.6±27.0 °C at 760 mmHg
[ Melting Point ]:
108-110 °C(lit.)
[ Molecular Formula ]:
C8H7ClO3
[ Molecular Weight ]:
186.592
[ Flash Point ]:
164.6±23.7 °C
[ Exact Mass ]:
186.008377
[ PSA ]:
57.53000
[ LogP ]:
1.33
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.610
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY1576300
- CHEMICAL NAME :
- Benzeneacetic acid, 3-chloro-4-hydroxy-
- CAS REGISTRY NUMBER :
- 33697-81-3
- BEILSTEIN REFERENCE NO. :
- 2096929
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C8-H7-Cl-O3
- MOLECULAR WEIGHT :
- 186.60
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 17,2087,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 2,9,1977
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
CY1576300
[ HS Code ]:
2918290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
J. Biol. Chem. 281(38) , 28318-25, (2006)
Halorespiration is a bacterial respiratory process in which haloorganic compounds act as terminal electron acceptors. This process is controlled at transcriptional level by CprK, a member of the ubiqu...
Degradation of 4-chlorophenylacetic acid by a Pseudomonas species.J. Bacteriol. 146(1) , 64-8, (1981)
Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid wa...
[Microbial degradation and 4-chlorophenylacetic acid. Chemical synthesis of 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy- and 4-chloro-2-hydroxyphenylacetic acid (author's transl)].Hoppe. Seylers. Z. Physiol. Chem. 363(4) , 431-7, (1982)
Pseudomonas spec. CBS 3 converts 4-chlorophenylacetic acid partly into 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy-, and 4-chloro-2-hydroxyphenylacetic acid by the action of monooxygenases. However, these...