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Britannin

Names

[ CAS No. ]:
33627-28-0

[ Name ]:
Britannin

[Synonym ]:
britanin
2α,6α-diacetoxy-4β-hydroxy-11(13)-pseudoguaien-12,8α-olide

Biological Activity

[Description]:

Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Inflammation/Immunology

[References]

[1]. Cui YQ The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS. Biochem Biophys Res Commun. 2018 Mar 11;497(3):916-923.

[2]. Park HH, et al. Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells. Int Immunopharmacol. 2013 Feb;15(2):296-302.

[3]. Moghadam MH, et al. Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana. Nat Prod Commun. 2012 Aug;7(8):979-80.

Chemical & Physical Properties

[ Density]:
1.25±0.1 g/cm3

[ Melting Point ]:
189-191 ºC

[ Molecular Formula ]:
C19H26O7

[ Molecular Weight ]:
366.40600

[ Exact Mass ]:
366.16800

[ PSA ]:
99.13000

[ LogP ]:
1.37450

[ Water Solubility ]:
Slightly soluble (2.7 g/L) (25 ºC)

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds