(2S)-Butan-2-yl 2-(3-[4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl)acetate

Names

[ Name ]:
(2S)-Butan-2-yl 2-(3-[4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl]-1-benzofuran-2-yl)acetate

[Synonym ]:
Budiodarone (USAN/INN)
BUDIODARONE

Biological Activity

[Description]:

Budiodarone (ATI-2042) is an analogue of Amiodarone (HY-14187) with a half-life of 7 h. Budiodarone inhibits sodium, potassium, and calcium ion channels. Budiodarone is an antiarrhythmic agent and can be used for the research of atrial fibrillation[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Arya A, et al. A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology. Europace. 2009 Apr;11(4):458-64.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₁I₂NO₅

[ Molecular Weight ]:
703.35

[ Exact Mass ]:
703.02900

[ PSA ]:
68.98000

[ LogP ]:
6.47780

Related Compounds

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