2-Pyridylethylamine dihydrochloride

Names

[ Name ]:
2-Pyridylethylamine dihydrochloride

[Synonym ]:
2-PYRIDINEETHANAMINE DIHYDROCHLORIDE
2-Pyridylethylamine dihydrochloride
C7H10N2.2HCl

Biological Activity

[Description]:

2-Pyridylethylamine is a histamine-1 (H1R) receptor agonist. 2-Pyridylethylamine can reduce the joint injury induced by formalin in rats. 2-Pyridylethylamine can be used to study the spinal cord release of neuropeptide (NPY) [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Souza-Silva E, et al. Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model. Brain Res. 2020 May 15;1735:146757.

Chemical & Physical Properties

[ Density]:
1.025g/cm3

[ Boiling Point ]:
207.9ºC at 760mmHg

[ Molecular Formula ]:
C₇H₁₂Cl₂N₂

[ Molecular Weight ]:
195.09

[ Flash Point ]:
100.6ºC

[ Exact Mass ]:
194.03800

[ PSA ]:
38.91000

[ LogP ]:
2.88710

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1819170

CHEMICAL NAME :: Pyridine, 2-(2-aminoethyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 3343-39-3

LAST UPDATED :: 198712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H10-N2.2Cl-H

MOLECULAR WEIGHT :: 195.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 30,178,1967

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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