N1-Cyclohexylpropane-1,3-diamine

Names

[ Name ]:
N1-Cyclohexylpropane-1,3-diamine

[Synonym ]:
N1-Cyclohexylpropane-1,3-diamine
MFCD00003838
N-Cyclohexylpropane-1,3-diamine
EINECS 222-001-7
3-amino-1-cyclohexylaminopropane
N-Cyclohexyl-1,3-diaminopropane
1-(Cyclohexylamino)-3-aminopropane
N-Cyclohexyltrimethylendiamin
3-(Aminopropyl)cyclohexylamine
3-(Cyclohexylamino)-1-propylamine
1,3-Propanediamine, N-cyclohexyl-
3-Cyclohexylaminopropylamine
N-Cyclohexyl-1,3-propanediamine
Cyclohexylamine, N-(3-aminopropyl)-
N-(3-Aminopropyl)cyclohexylamine
N-Cyclohexylpropylene 1,3-diamine
3-Cyclohexylamino-1-propylamine
Cyclohexyl-1,3-propanediamine
N-Cyclohexyl-1,3-propylenediamine
3-Cyclohexylaminopropylamin

Biological Activity

[Description]:

N-(3-Aminopropyl)cyclohexylamine, a cyclohexylamine derivative, acts as a selective and competitive inhibitor of spermidine synthase. N-(3-Aminopropyl)cyclohexylamine can be used for the research of neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. P J Chu, et al.Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Jpn J Pharmacol. 1995 Dec;69(4):311-5.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
238.7±8.0 °C at 760 mmHg

[ Melting Point ]:
−17-−15 °C(lit.)

[ Molecular Formula ]:
C₉H₂₀N₂

[ Molecular Weight ]:
156.268

[ Flash Point ]:
112.3±22.0 °C

[ Exact Mass ]:
156.162643

[ PSA ]:
38.05000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.484

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
1

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues.

Biochem. Pharmacol. 45(9) , 1897-903, (1993)

Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynt...

Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.

J. Biochem. 117(2) , 339-45, (1995)

The effects of a potent spermidine synthase inhibitor, trans-4-methylcyclohexylamine (4MCHA), and a spermine synthase inhibitor, N-(3-aminopropyl)cyclohexylamine (APCHA), on polyamine biosynthesis and...

Inhibition of cell growth by combination of alpha-difluoromethylornithine and an inhibitor of spermine synthase.

J. Biochem. 117(4) , 824-9, (1995)

The inhibitory effect on cell growth of a combination of alpha-difluoromethylornithine (DFMO) and an inhibitor of aminopropyl transferase was examined. N-(3-aminopropyl)cyclohexylamine (APCHA) and tra...

Related Compounds

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