3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid

Names

[ Name ]:
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid

[Synonym ]:
1H-Benz[e]indene-6-propanoic acid, 7-(1-carboxyethylidene)-3-[(1R,4E)-5-carboxy-1-methyl-4-hexen-1-yl]dodecahydro-3a,5a,9b-trimethyl-, (3R,3aR,5aS,7Z,9aR,9bS)-
(2E,6R)-6-[(3R,3aR,5aS,7Z,9aR,9bS)-6-(2-Carboxyethyl)-7-(1-carboxyethylidene)-3a,5a,9b-trimethyldodecahydro-1H-cyclopenta[a]naphthalen-3-yl]-2-methyl-2-heptenoic acid

Biological Activity

[Description]:

(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor, with an IC50 of 0.4 μM. (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent PTP1B inhibitory activity without cytotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 0.4 μM (PTP1B)[1]

[References]

[1]. Maarisit W, et al. Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida. J Nat Med. 2017 Jan;71(1):334-337.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
669.2±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₄₈O₆

[ Molecular Weight ]:
516.71

[ Flash Point ]:
372.5±18.3 °C

[ Exact Mass ]:
502.329437

[ PSA ]:
111.90000

[ LogP ]:
8.45

[ Vapour Pressure ]:
0.0±4.4 mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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