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Remogliflozin A

Names

[ CAS No. ]:
329045-45-6

[ Name ]:
Remogliflozin A

[Synonym ]:
Remogliflozin A
UNII-13ZPK7A4MJ
[14C]-Remogliflozin

Biological Activity

[Description]:

Remogliflozin is a potent and selective inhibitor of SGLT2 (sodium-glucose cotransporter 2) with Kis of 12.4 and 26 nM for human and rat SGLT2, respectively[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT

[References]

[1]. Fujimori Y, et al. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H34N2O7

[ Molecular Weight ]:
450.53

[ Exact Mass ]:
450.23700

[ PSA ]:
126.43000

[ LogP ]:
1.32910

Synthetic Route

Click to get detail synthetic route

Related Compounds