DNMDP

Names

[ Name ]:
DNMDP

[Synonym ]:
6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
3(2H)-Pyridazinone, 6-[4-(diethylamino)-3-nitrophenyl]-4,5-dihydro-5-methyl-
MFCD01829240

Biological Activity

[Description]:

DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12); coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity.

[References]

References 1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8. 2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043. View Related Products by Target Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₂₀N₄O₃

[ Molecular Weight ]:
304.344

[ Exact Mass ]:
304.153534

[ LogP ]:
1.49

[ Index of Refraction ]:
1.613

[ Storage condition ]:
-20°C

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.