CH2COOH-PEG3-CH2COOH

Names

[ Name ]:
CH2COOH-PEG3-CH2COOH

[Synonym ]:
3,6,9,12-tetraoxatetradecanedioic acid
3,6,9,12-tetraoxa-1,14-tetradecandioic acid
triethyleneglycol diacetic acid
triethyleneglycol diglycolide
TEG-diGL

Biological Activity

[Description]:

CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₈O₈

[ Molecular Weight ]:
266.24500

[ Exact Mass ]:
266.10000

[ PSA ]:
111.52000

Safety Information

[ Hazard Codes ]:
C

Related Compounds

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