SU11652

Names

[ Name ]:
SU11652

[Synonym ]:
in1074

Biological Activity

[Description]:

SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and Kit. SU11652 can be uesd for spontaneous cancers expressing Kit mutations research[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Kit

[Target]

IC50: 0.01 μM (PDGFR), 0.03 μM (Flk-1), 0.05 μM (c-kit)[1]

[In Vitro]

SU11652 (0-1 μM, 0-72 h) inhibits the growth of mast cell lines expressing mutant Kit[1]. SU11652 (0-1 μM, 0-72 h) induces cell cycle arrest followed by apoptosis in cell lines expressing mutant Kit[1].

[References]

[1]. Liao AT, et al. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002;100(2):585-593.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₇ClN₄O₂

[ Molecular Weight ]:
414.93

[ Exact Mass ]:
414.18200

[ PSA ]:
77.23000

[ LogP ]:
4.37810

Related Compounds

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