Isofebrifugine

Names

[ Name ]:
Isofebrifugine

[Synonym ]:
(+)-inthomycin A
Phthoxazolin A
4,6,8-Decatrienamide,3-hydroxy-2,2,4-trimethyl-10-(5-oxazolyl)-,(R-(Z,Z,E))
Phthoxazolin
(R-(Z,Z,E))-3-Hydroxy-2,2,4-trimethyl-10-(5-oxazolyl)-4,6,8-decatrienamide

Biological Activity

[Description]:

Isofebrifugine, isolated from a Chinese medicinal plant, Chang Shan (Dichroa febrifuga), is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Kobayashi S, et al. Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.J Org Chem. 1999 Sep 3;64(18):6833-6841.

Chemical & Physical Properties

[ Density]:
1.48±0.1 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
519.8±58.0 °C(Predicted)

[ Melting Point ]:
138-139 ºC

[ Molecular Formula ]:
C₁₆H₁₉N₃O₃

[ Molecular Weight ]:
301.34000

[ Exact Mass ]:
301.14300

[ PSA ]:
76.38000

[ LogP ]:
0.95480

[ Water Solubility ]:
Very slightly soluble (0.28 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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