Melphalan hydrochloride
Names
[ CAS No. ]:
3223-07-2
[ Name ]:
Melphalan hydrochloride
[Synonym ]:
DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride
DL-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride
L-phenylalanine, 4-[bis(2-chloroethyl)amino]-, monohydrochloride
4-[Bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride (1:1)
acide (2S)-2-amino-3-{4-[bis(2-chloroéthyl)amino]phényl}propanoïque chlorhydrate
DL-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride (9CI)
L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride (9CI)
(2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid hydrochloride
4-(Bis(2-chloroethyl)amino)-L-phenylalanine Monohydrochloride
3-(p-(Bis(β-chloroethyl)amino)phenyl)-D,L-alanine hydrochloride
4-(Bis(2-chloroethyl)amino)-DL-phenylalanine hydrochloride
Melphalan Hydrochloride,Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
(2S)-2-Amino-3-{4-[bis(2-chlorethyl)amino]phenyl}propansäurehydrochlorid
3-[p-[Bis(β-chloroethyl)amino]phenyl]-D,L-alanine, hydrochloride
4-[bis(2-chloroethyl)amino]-L-phenylalanine hydrochloride
L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
3-(p-(Bis(2-chloroethyl)amino)phenyl)-DL-alanine hydrochloride
DL-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-, hydrochloride
L-Alanine, 3-(p-[bis(2-chloroethyl)amino]phenyl)-, hydrochloride
3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine Hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
473.1ºC at 760mmHg
[ Molecular Formula ]:
C13H19Cl3N2O2
[ Molecular Weight ]:
341.661
[ Flash Point ]:
239.9ºC
[ Exact Mass ]:
340.051208
[ PSA ]:
66.56000
[ LogP ]:
3.42730
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY4025000
- CHEMICAL NAME :
- Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, monohydrochloride, L-
- CAS REGISTRY NUMBER :
- 3223-07-2
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C13-H18-Cl2-N2-O2.Cl-H
- MOLECULAR WEIGHT :
- 341.69
- WISWESSER LINE NOTATION :
- QVYZ1R DN2G2G &GH -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1200 ug/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- REFERENCE :
- CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 57,369,1973
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 430 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia Blood - other changes
- REFERENCE :
- CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 430 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - agranulocytosis Blood - other changes
- REFERENCE :
- CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 ug/kg/4W
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 36,915,1966
Safety Information
[ Hazard Codes ]:
Xn
[ HS Code ]:
2922499990
Customs
[ HS Code ]: 2922499990
[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%