ZINC00784494

ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC)[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

LCN2[1].

ZINC00784494 (0.01-100 µM; 72 h) reduces cell proliferation and cell viability in SUM149 cells[1]. ZINC00784494 (1, 10 µM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells[1]. Cell Viability Assay[1] Cell Line: SUM149 cells Concentration: 0.01-100 µM Incubation Time: 72 h Result: Reduced cell viability at concentrations of 1 µM or lower. Western Blot Analysis[1] Cell Line: SUM149 cells Concentration: 1, 10 µM Incubation Time: 15 min, 1 h, 24 h Result: Reduced the p-Akt protein levels 15 min and 1 h and changes in the p-Akt protein levels were not observed at 24 h.