Tiamenidine

Names

[ Name ]:
Tiamenidine

[Synonym ]:
Hoe-440
Tiamenidinum
Hoe-42-440
Tiamenidine
Tiamenidina

Biological Activity

[Description]:

Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

IC50: α2-Adrenergic Receptor[1]

[References]

[1]. D M Roden, et al. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther. 1988 Jun;43(6):648-54.

Chemical & Physical Properties

[ Density]:
1.52g/cm3

[ Boiling Point ]:
305.1ºC at 760mmHg

[ Melting Point ]:
152°

[ Molecular Formula ]:
C₈H₁₀ClN₃S

[ Molecular Weight ]:
215.70

[ Flash Point ]:
138.3ºC

[ Exact Mass ]:
215.02800

[ PSA ]:
64.66000

[ LogP ]:
1.91840

[ Index of Refraction ]:
1.717

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%