migrastatin

Names

[ Name ]:
migrastatin

[Synonym ]:
Migrastatin
4-[(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione
4-{(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl}piperidine-2,6-dione

Biological Activity

[Description]:

Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Fascin1[1]

[In Vitro]

Migrastatin (100 μM) leads to the disorganization of the bundles. Migrastatin (100 μM; HCT-116 and DLD-1 cells) prevents cell migration[1].

[References]

[1]. Montoro-García S, et al. Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. J Mol Med (Berl). 2020;98(3):383-394.

[2]. Nakae K, et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000;53(10):1130-1136.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₉NO₇

[ Molecular Weight ]:
489.60100

[ Exact Mass ]:
489.27300

[ PSA ]:
122.49000

[ LogP ]:
3.46690

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.