Retro 1

Names

[ Name ]:
Retro 1

[Synonym ]:
2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3,4,5-tetrahydro-4-(1-oxopropyl)-5-phenyl-
MFCD00807208
7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one

Biological Activity

[Description]:

Retro 1 is the first small molecule inhibitor of plant toxin ricin, protects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface; has no effect on endogenous retrograde cargo proteins; protects mice against ricin challenge.

[References]

References 1. Stechmann B, et al. Cell. 2010 Apr 16;141(2):231-42. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
544.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇BrN₂O₂

[ Molecular Weight ]:
373.244

[ Flash Point ]:
282.9±30.1 °C

[ Exact Mass ]:
372.047333

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.604

Related Compounds

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