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4-Octyl Itaconate

Names

[ CAS No. ]:
3133-16-2

[ Name ]:
4-Octyl Itaconate

[Synonym ]:
Butanedioic acid,methylene-,4-octyl ester
4-Octyl Itaconate

Biological Activity

[Description]:

4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[Target]

Nrf2[1]


[In Vivo]

4-Octyl Itaconate (OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production[1].

[References]

[1]. Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.


[Related Small Molecules]

ML385 | Curcumin | Bardoxolone Methyl | tert-Butylhydroquinone | RTA-408 | CDDO-Im | NK 252 | Brusatol | Danshensu | KI696 | CDDO-EA | (+)-DHMEQ | Hinokitiol | Mangiferin | Astilbin

Chemical & Physical Properties

[ Molecular Formula ]:
C13H22O4

[ Molecular Weight ]:
242.31

[ PSA ]:
66.43000

[ LogP ]:
1.58470

[ Storage condition ]:
2-8℃

Related Compounds