SR31527

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.

References 1. Zhang W, et al. Biochem J. 2016 Apr 15;473(8):1027-35. 2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41. View Related Products by Target Kinesin