SYM 2081

Names

[ Name ]:
SYM 2081

[Synonym ]:
(2S,4R)-4-Methylglutamic acid
(2S,4R)-2-azaniumyl-4-methylpentanedioate
MFCD00937765

Biological Activity

[Description]:

SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 35 nM (kainate receptors)[1]

[References]

[1]. Lee JY, et al. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150(4):546-57.

Chemical & Physical Properties

[ Boiling Point ]:
329.4ºC at 760mmHg

[ Molecular Formula ]:
C₆H₁₁NO₄

[ Molecular Weight ]:
161.16

[ Flash Point ]:
153ºC

[ Exact Mass ]:
161.06900

[ PSA ]:
100.62000

[ LogP ]:
0.20940

[ Appearance of Characters ]:
solid | white

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
H2O: >10 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Related Compounds

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