Fargesin

Names

[ Name ]:
Fargesin

[Synonym ]:
Fargesin
1,3-Benzodioxole, 5-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-
5-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole
(+)-demethoxyaschantin
methyl piperitol
(+)-kobusin
Methyl pluviatilol
UNII:GR9853GI71

Biological Activity

[Description]:

Fargesin is a bioactive neolignan isolated from magnolia plants，with antihypertensive and anti-inflammatory effects[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[In Vitro]

Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB[3]. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis[4].

[In Vivo]

Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release[1].

[References]

[1]. Sha S, et al. Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release. Can J Physiol Pharmacol. 2016 Aug;94(8):900-6.

[2]. Yue B, et al. Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice. Molecules. 2018 Jun 7;23(6).

[3]. Pham TH, et al. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling. Phytomedicine. 2017 Jan 15;24:96-103.

[4]. Wang X, et al. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia. 2015 Sep;105:16-25.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
506.4±50.0 °C at 760 mmHg

[ Melting Point ]:
132.0 to 136.0 °C

[ Molecular Formula ]:
C₂₁H₂₂O₆

[ Molecular Weight ]:
370.396

[ Flash Point ]:
208.9±30.0 °C

[ Exact Mass ]:
370.141632

[ PSA ]:
55.38000

[ LogP ]:
3.20

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds

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