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1-Isopropyl-1H-benzotriazole-5-carboxylic acid

Names

[ CAS No. ]:
306935-41-1

[ Name ]:
1-Isopropyl-1H-benzotriazole-5-carboxylic acid

[Synonym ]:
1-Isopropyl-1H-benzotriazole-5-carb; oxylic acid
MFCD01570664
1H-1,2,3-Benzotriazole-5-carboxylic acid, 1-(1-methylethyl)-
1-(propan-2-yl)-1H-benzotriazole-5-carboxylic acid
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
1-Isopropyl-1H-benzotriazole-5-carboxylic acid
1-Isopropylbenzotriazole-5-carboxylic acid
FSLLRY-NH2
1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid

Biological Activity

[Description]:

GPR109 receptor agonist-1 (Compound 3a) is a highly selective agonist of the human orphan G-protein-coupled receptor GPR109b, with the pEC50 of 6.4. GPR109 receptor agonist-1 can be used for the research of cardio-metabolic diseases[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> GPR109A
Research Areas >> Metabolic Disease

[Target]

pEC50: 6.40 ± 0.36 (GPR109b)[1]


[References]

[1]. Graeme Semple, et al. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem. 2006 Feb 23;49(4):1227-30.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
413.9±18.0 °C at 760 mmHg

[ Melting Point ]:
229-230ºC

[ Molecular Formula ]:
C10H11N3O2

[ Molecular Weight ]:
205.213

[ Flash Point ]:
204.1±21.2 °C

[ Exact Mass ]:
205.085129

[ PSA ]:
68.01000

[ LogP ]:
2.05

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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