Bisabolangelone

Names

[ Name ]:
Bisabolangelone

[Synonym ]:
Bisabolangelon

Biological Activity

[Description]:

Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities[1][2].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

[References]

[1]. Jung HW, et al. Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells. Int Immunopharmacol. 2010 Feb;10(2):155-62.

[2]. Wang J, et al. The anti-ulcer activities of bisabolangelone from Angelica polymorpha. J Ethnopharmacol. 2009 Jun 22;123(2):343-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₀O₃

[ Molecular Weight ]:
248.31700

[ Exact Mass ]:
248.14100

[ PSA ]:
46.53000

[ LogP ]:
2.52160

[ Storage condition ]:
2-8℃

Related Compounds

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