Triethylene glycol monododecyl ether

Names

[ Name ]:
Triethylene glycol monododecyl ether

[Synonym ]:
Lauryltriglycol ether
Triethylene glycol monododecyl ether
triiethylene glycol mondodecyl ether
PEG-3 Lauryl ether
Ethanol, 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]-
C12E3 Dodecyl triethylene glycol ether Dodecyltriglycol Polyoxyethylene (3) lauryl ether
Dodecyltriglycol
2-{2-[2-(Dodecyloxy)ethoxy]ethoxy}ethanol
TRIETHYLENE GLYCOL MONO-N-DODECYL ETHER
triethyleneglycol monododecyl ether
Dodecyl triethylene glycol ether
Lauryl triethoxylate
MFCD00042659
Detergent Screening
EINECS 221-280-2
Triethylene glycol dodecyl ether
Triethyleneglycol monododecyl ether 1 mM
Lauryl alcohol triglycol ether

Biological Activity

[Description]:

Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
412.0±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₃₈O₄

[ Molecular Weight ]:
318.492

[ Flash Point ]:
202.9±23.2 °C

[ Exact Mass ]:
318.277008

[ PSA ]:
47.92000

[ LogP ]:
4.33

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.451

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK7870000

CHEMICAL NAME :: Ethanol, 2-(2-(2-(dodecyloxy)ethoxy)ethoxy)-

CAS REGISTRY NUMBER :: 3055-94-5

BEILSTEIN REFERENCE NO. :: 1779029

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H38-O4

MOLECULAR WEIGHT :: 318.56

WISWESSER LINE NOTATION :: Q2O2O2O12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - guinea pig Kidney

DOSE/DURATION :: 10 umol/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,431,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
KK7870000

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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