8-Demethyl Ivabradine

Names

[ Name ]:
8-Demethyl Ivabradine

[Synonym ]:
8-Demethyl Ivabradine
2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-8-hydroxy-7-methoxy-
3-{3-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-8-hydroxy-7-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-8-hydroxy-7-methoxy-2H-3-benzazepin-2-one

Biological Activity

[Description]:

8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker[1].

[Related Catalog]:

Research Areas >> Endocrinology

[References]

[1]. M François-Bouchard,et al. Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography--tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):261-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
643.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₄N₂O₅

[ Molecular Weight ]:
454.559

[ Flash Point ]:
343.2±31.5 °C

[ Exact Mass ]:
454.246765

[ PSA ]:
71.47000

[ LogP ]:
2.92

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds

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