JB002

Names

[ Name ]:
JB002

Biological Activity

[Description]:

JB002 is a myosin II inhibitor, with an IC50 of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cytoskeleton >> Myosin

[Target]

IC50: ≤10 μM (myosin II)[1]

[In Vitro]

JB002 在心脏和骨骼肌球蛋白之间表现出良好的选择性，但对非肌肉 IIB 没有可检测的活性[1]。

[References]

[1]. Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅NO₃

[ Molecular Weight ]:
293.32

Related Compounds

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