2-Aminotetralin
Names
[ CAS No. ]:
2954-50-9
[ Name ]:
2-Aminotetralin
[Synonym ]:
1-Naphthalenol,1,2,3,4-tetrahydro-,benzoate
1-Benzoyloxy-1.2.3.4-tetrahydro-naphthalin
1,2,3,4-tetrahydronaphth-2-ylamine
2-Aminotetralin
Aminotetralin
1,2,3,4-tetrahydronaphthalen-1-yl benzoate
2-amino-1,2,3,4-tetrahydronaphthalene
1,2,3,4-Tetrahydro-2-naphthalenamine
2-amino-tetralin
2-R-amino-tetraline
2-Naphthalenamine, 1,2,3,4-tetrahydro-
1,2,3,4-tetrahydro-1-naphthyl benzoate
THN
1,2,3,4-Tetrahydronaphthalen-2-amine
1,2,3,4-tetrahydro-naphth-1-yl benzoate
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
250.7±29.0 °C at 760 mmHg
[ Melting Point ]:
149-151 °C
[ Molecular Formula ]:
C10H13N
[ Molecular Weight ]:
147.217
[ Flash Point ]:
111.6±19.6 °C
[ Exact Mass ]:
147.104797
[ PSA ]:
26.02000
[ LogP ]:
2.09
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.561
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QM4900000
- CHEMICAL NAME :
- 2-Naphthylamine, 1,2,3,4-tetrahydro-
- CAS REGISTRY NUMBER :
- 2954-50-9
- BEILSTEIN REFERENCE NO. :
- 1102357
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C10-H13-N
- MOLECULAR WEIGHT :
- 147.24
- WISWESSER LINE NOTATION :
- L66&TJ HZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,466,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,466,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,168,1965
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Vascular - regional or general arteriolar constriction Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,70,1928
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,168,1965
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- APAVAY Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. (Berlin, Ger.) V.1-343, 1847-1967. For publisher information, see VAAPB7. Volume(issue)/page/year: 115,14,1889 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959
Safety Information
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36/37/39
[ HS Code ]:
2921450090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921450090
[ Summary ]:
2921450090 1-naphthylamine (α-naphthylamine), 2-naphthylamine (β-naphthylamine) and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%