H-Pro-Gly-NH2 · HCl

Names

[ Name ]:
H-Pro-Gly-NH2 · HCl

[Synonym ]:
Ozarelix
N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N6-(aminocarbonyl)-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-D-alaninamide
D 63153
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N-(aminocarbonyl)-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-
D-63153
N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-N-carbamoyl-D-lysyl-L-norleucyl-L-arginyl-L-prolyl-D-alaninamide
UNII-Q1IF8M2YL3

Biological Activity

[Description]:

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Ozarelix (0-20 ng/mL, 72 h) inhibits PC3 and DU145 cell proliferation[1]. Ozarelix (0-20 ng/mL, 72 h) induces apoptosis in PC3 and DU145 cells[1]. Ozarelix (20 ng/mL, 72 h) triggers caspase 8-dependent caspase 3 activation[1]. Cell Proliferation Assay[1] Cell Line: Serum-starved PC3 and DU145 cells Concentration: 0, 5, 10, 20 ng/mL Incubation Time: 0, 24, 48, 72, 96 h Result: Inhibited cell proliferation in a dose and time-dependent manner. Western Blot Analysis[1] Cell Line: PC3 and DU145 cells Concentration: 0, 5, 10, 20 ng/mL Incubation Time: 72 h Result: Increased the levels of p21 and p27 both in PC3 and DU145 cells. Decreased levels of anti-apoptotic proteins such as Bcl2 and Bcl-Xl. Upregulated Erk and p38MAPK activity.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₇₂H₉₆ClN₁₇O₁₄

[ Molecular Weight ]:
1459.091

[ Exact Mass ]:
1457.701172

[ PSA ]:
486.88000

[ LogP ]:
3.42

[ Index of Refraction ]:
1.659

Related Compounds

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