YXG-158

Names

[ CAS No. ]:
2952994-34-0

[ Name ]:
YXG-158

Biological Activity

[Description]:

YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Androgen Receptor

[Target]

DC50: 1.28 μM (androgen receptor)[1]. IC50: 100 nM (CYP17A1)[1].


[References]

[1]. Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66(14):9972-9991.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H36FN3O

[ Molecular Weight ]:
473.62

Related Compounds

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