(6S,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Names
[ CAS No. ]:
2944-87-8
[ Name ]:
(6S,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
[Synonym ]:
6alpha-Hydroxytestosterone
6-hydroxytestosterone
4-androstene-6alpha,17beta-diol-3-one
Androst-4-ene-6|A,17|A-diol-3-one
4-Androstene-6|A,17|A-diol-3-one
6|A-Hydroxytestosterone
Chemical & Physical Properties
[ Density]:
1.19g/cm3
[ Boiling Point ]:
479.8ºC at 760 mmHg
[ Molecular Formula ]:
C19H28O3
[ Molecular Weight ]:
304.42400
[ Flash Point ]:
258.1ºC
[ Exact Mass ]:
304.20400
[ PSA ]:
57.53000
[ LogP ]:
2.85000
[ Vapour Pressure ]:
3.19E-11mmHg at 25°C
[ Index of Refraction ]:
1.578
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332-H351-H361
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22;R40;R63
[ Safety Phrases ]:
S22-S36
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Pediatr. Endocrinol. Metab. 23(1-2) , 143-52, (2010)
We describe the metabolite spectrum of testosterone (T) in human fetal adrenal in vitro, and verify possible roles of CYP3A and 2C isoforms of human fetal adrenal in T metabolism which respond to T me...
The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.Pharm. Res. 20(10) , 1591-4, (2003)
The hepatic and intestinal metabolic activities of P450 were evaluated in rats with surgery- and drug-induced renal dysfunction.Renal failure was induced by five-sixths nephrectomy (NR), bilateral ure...
The use of heat treatment to eliminate drug interactions due to grapefruit juice.Biol. Pharm. Bull. 29(11) , 2274-8, (2006)
Grapefruit juice (GJ) contains components that may increase the bioavailability of drugs; however, approaches to the removal of these components have been little investigated. It is known that furanoc...