Pim-1 kinase inhibitor 5

Names

[ CAS No. ]:
2928606-67-9

[ Name ]:
Pim-1 kinase inhibitor 5

Biological Activity

[Description]:

Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC50: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC50s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[References]

[1]. Mansour B, et al. Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation. ACS Omega. 2023 May 24;8(22):19351-19366.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H13Cl2N3O

[ Molecular Weight ]:
406.26

Related Compounds