hCAIX-IN-18

Names

[ CAS No. ]:
2925261-76-1

[ Name ]:
hCAIX-IN-18

Biological Activity

[Description]:

hCAIX-IN-18 (compound 30) is an inhibitor of carbonic anhydrase (CA), with Kis of 3.5 nM, 9.4 nM, 43.0 nM and 8.2 nM for hCAI, hCAII, hCAIX, hCAXII, respectively. hCAIX-IN-18 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

hCA I:3.5 nM (IC50)

hCA II:9.4 nM (IC50)

hCA IX:43 nM (IC50)

hCA XII:8.2 nM (IC50)


[References]

[1]. 1. Peerzada MN, et al. Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors. ACS Med Chem Lett. 2023 May 8;14(6):810-819.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19ClN4O3S

[ Molecular Weight ]:
394.88