PD-1/PD-L1-IN-34

Names

[ Name ]:
PD-1/PD-L1-IN-34

Biological Activity

[Description]:

PD-1/PD-L1-IN-30 (Compound (1S,2S)-A25) inhibits PD-1/PD-L1 interaction (IC50=0.029 μM), with a selected binding affinity with PD-L1 (KD=0.1554 μM). PD-1/PD-L1-IN-30 inhibits tumor growth by activating the immune microenvironment[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

Research Areas >> Inflammation/Immunology

[References]

[1]. Jing T, et al. Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors. J Med Chem. 2023 May 25;66(10):6811-6835.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₃₃ClN₂O₃

[ Molecular Weight ]:
565.10

Related Compounds

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