ER degrader 6

Names

[ CAS No. ]:
2922929-62-0

[ Name ]:
ER degrader 6

Biological Activity

[Description]:

ER degrader 6 (compound 35s) is a potent Estrogen Receptor (ER)α degrader. ER degrader 6 disrupts the microtubule network by restraining tubulin polymerization. ER degrader 6 suppresses tumor growth without noticeable poisonousness[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Cancer

[Target]

ERα


[References]

[1]. Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H34FN3O5SSe

[ Molecular Weight ]:
682.66

Related Compounds

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